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<title>Pyoderma gangrenosum</title>

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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">Pyoderma gangrenosum</span></span>

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</style><div role="note" class="hatnote navigation-not-searchable">Not to be confused with <a href="Ecthyma_gangrenosum" title="Ecthyma gangrenosum">ecthyma gangrenosum</a>.</div><style data-mw-deduplicate="TemplateStyles:r1295905060">

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</style><table class="infobox infobox-has-images-with-white-backgrounds"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Pyoderma gangrenosum</th></tr><tr><td colspan="2" class="infobox-full-data"></td></tr><tr><td colspan="2" class="infobox-full-data">Pyoderma gangrenosum on the leg of a person with ulcerative colitis.</td></tr><tr><th scope="row" class="infobox-label"><a href="Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="Dermatology" title="Dermatology">Dermatology</a> <span class="penicon autoconfirmed-show"></span></td></tr><tr><th scope="row" class="infobox-label">Usual onset</th><td class="infobox-data">40s or 50s<sup id="cite_ref-Jack2012_1-0" class="reference"><a href="#cite_note-Jack2012-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label">Treatment</th><td class="infobox-data"><a href="Corticosteroids" class="mw-redirect" title="Corticosteroids">Corticosteroids</a>, <a href="Ciclosporin" title="Ciclosporin">ciclosporin</a>, <a href="Infliximab" title="Infliximab">infliximab</a>, <a href="Canakinumab" title="Canakinumab">canakinumab</a><sup id="cite_ref-Part2018_2-0" class="reference"><a href="#cite_note-Part2018-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></td></tr></tbody></table><style data-mw-deduplicate="TemplateStyles:r1236303919">

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<p><b>Pyoderma gangrenosum</b> is a rare, <a href="Inflammation" title="Inflammation">inflammatory</a> skin disease where painful <a href="Pustule" class="mw-redirect" title="Pustule">pustules</a> or <a href="Skin_condition" title="Skin condition">nodules</a> become <a href="Ulcer_(dermatology)" title="Ulcer (dermatology)">ulcers</a> that progressively grow.<sup id="cite_ref-RuoccoSangiuliano2009_3-0" class="reference"><a href="#cite_note-RuoccoSangiuliano2009-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Pyoderma gangrenosum is not infectious.<sup id="cite_ref-RuoccoSangiuliano2009_3-1" class="reference"><a href="#cite_note-RuoccoSangiuliano2009-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>

</p><p>Treatments may include <a href="Corticosteroids" class="mw-redirect" title="Corticosteroids">corticosteroids</a>, <a href="Ciclosporin" title="Ciclosporin">ciclosporin</a>, <a href="Infliximab" title="Infliximab">infliximab</a>, or <a href="Canakinumab" title="Canakinumab">canakinumab</a>.<sup id="cite_ref-Part2018_2-1" class="reference"><a href="#cite_note-Part2018-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>

</p><p>The disease was identified in 1908. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.<sup id="cite_ref-Jack2012_1-1" class="reference"><a href="#cite_note-Jack2012-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Types">Types</h2></div>

<p>There are two main types of pyoderma gangrenosum:<sup id="cite_ref-Jack2012_1-2" class="reference"><a href="#cite_note-Jack2012-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>

</p>

<ul><li>the 'typical' ulcerative form, which occurs in the legs</li>

<li>an 'atypical' form that is more superficial and occurs in the hands and other parts of the body</li></ul>

<p>Other variations are:<sup id="cite_ref-pmid16858047_4-0" class="reference"><a href="#cite_note-pmid16858047-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>

</p>

<ul><li>Peristomal pyoderma gangrenosum comprises 15% of all cases of pyoderma</li>

<li><a href="Bullous" class="mw-redirect" title="Bullous">Bullous</a> pyoderma gangrenosum</li>

<li><a href="Pustular" class="mw-redirect" title="Pustular">Pustular</a> pyoderma gangrenosum<sup id="cite_ref-pmid14616824_5-0" class="reference"><a href="#cite_note-pmid14616824-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li>

<li><a href="https://en.wiktionary.org/wiki/vegetative" class="extiw external" title="wikt:vegetative">Vegetative</a> pyoderma gangrenosum<sup id="cite_ref-pmid16101860_6-0" class="reference"><a href="#cite_note-pmid16101860-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li></ul>

<div class="mw-heading mw-heading2"><h2 id="Presentation">Presentation</h2></div>

<div class="mw-heading mw-heading3"><h3 id="Associations">Associations</h3></div>

<p>The following are conditions commonly associated with pyoderma gangrenosum:<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>

</p>

<ul><li>Inflammatory bowel disease:

<ul><li><a href="Ulcerative_colitis" title="Ulcerative colitis">Ulcerative colitis</a></li>

<li><a href="Crohn's_disease" title="Crohn's disease">Crohn's disease</a></li></ul></li>

<li>Arthritides:

<ul><li><a href="Rheumatoid_arthritis" title="Rheumatoid arthritis">Rheumatoid arthritis</a></li>

<li><a href="Seronegative_arthritis" class="mw-redirect" title="Seronegative arthritis">Seronegative arthritis</a></li></ul></li>

<li>Hematological disease:

<ul><li><a href="Myelocytic_leukemia" class="mw-redirect" title="Myelocytic leukemia">Myelocytic leukemia</a><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li>

<li><a href="Hairy_cell_leukemia" title="Hairy cell leukemia">Hairy cell leukemia</a></li>

<li><a href="Myelofibrosis" class="mw-redirect" title="Myelofibrosis">Myelofibrosis</a></li>

<li><a href="Myeloid_metaplasia" class="mw-redirect" title="Myeloid metaplasia">Myeloid metaplasia</a></li>

<li><a href="Monoclonal_gammopathy" title="Monoclonal gammopathy">Monoclonal gammopathy</a></li></ul></li>

<li>Solid tumors</li></ul>

<p>A rare<sup id="cite_ref-genovese2020_10-0" class="reference"><a href="#cite_note-genovese2020-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> syndromic association called pyogenic arthritis, pyoderma gangrenosum and acne syndrome (<a href="PAPA_syndrome" title="PAPA syndrome">PAPA syndrome</a>), a type of <a href="Autoinflammatory_disorder" class="mw-redirect" title="Autoinflammatory disorder">autoinflammatory disorder</a>, is associated with mutations in the proline-serine-threonine phosphatase-interacting 1 gene (<i><a href="PSTPIP1" title="PSTPIP1">PSTPIP1</a></i>).<sup id="cite_ref-genovese2020_10-1" class="reference"><a href="#cite_note-genovese2020-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-smith2010_11-0" class="reference"><a href="#cite_note-smith2010-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Causes">Causes</h2></div>

<p>Though the cause is not well understood, the disease is thought to be due to <a href="Immune_system" title="Immune system">immune system</a> dysfunction, and particularly improper functioning of <a href="Neutrophil_granulocyte" class="mw-redirect" title="Neutrophil granulocyte">neutrophils</a>. In support of an immune cause, a variety of immune mediators such as <a href="Interleukin_8" title="Interleukin 8">interleukin (IL)-8</a>, <a href="Interleukin_1_beta" title="Interleukin 1 beta">IL-1β</a>, <a href="Interleukin_6" title="Interleukin 6">IL-6</a>, <a href="Interferon_gamma" title="Interferon gamma">interferon (IFN)-γ</a>, <a href="Granulocyte_colony-stimulating_factor" title="Granulocyte colony-stimulating factor">granulocyte colony-stimulating factor</a>, <a href="Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">tumor necrosis factor alpha</a>, <a href="MMP9" title="MMP9">matrix metalloproteinase (MMP)-9</a>, <a href="MMP10" title="MMP10">MMP10</a>, and <a href="Elafin" title="Elafin">elafin</a> have all been reported to be elevated in patients with pyoderma gangrenosum.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup>

</p><p>Also in support of an immune cause is the finding that at least half of all pyoderma gangrenosum patients suffer from immune-mediated diseases.<sup id="cite_ref-Jack2012_1-3" class="reference"><a href="#cite_note-Jack2012-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> For instance, <a href="Ulcerative_colitis" title="Ulcerative colitis">ulcerative colitis</a>, <a href="Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>,<sup id="cite_ref-pmid16858047_4-1" class="reference"><a href="#cite_note-pmid16858047-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> and <a href="Monoclonal_gammopathy" title="Monoclonal gammopathy">monoclonal gammopathies</a><sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> have all been associated with pyoderma gangrenosum. It can also be part of autoinflammatory syndromes such as PAPA syndrome.<sup id="cite_ref-genovese2020_10-2" class="reference"><a href="#cite_note-genovese2020-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-smith2010_11-1" class="reference"><a href="#cite_note-smith2010-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Marzano et al. (2017) identified a variety of <a href="Single-nucleotide_polymorphism" title="Single-nucleotide polymorphism">single-nucleotide polymorphisms</a> (SNPs) linked to autoinflammation that were carried, singly or in combination, in subsets of patients with pyoderma gangrenosum, acne and suppurative hidradenitis syndrome (PASH syndrome) or isolated pyoderma gangrenosum of the ulcerative subtype.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup>

</p><p>One hallmark of pyoderma gangrenosum is <a href="Pathergy" title="Pathergy">pathergy</a>, which is the appearance of new lesions at sites of trauma, including surgical wounds.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2></div>

<p>Diagnosis of PG is challenging owing to its variable presentation, clinical overlap with other conditions, association with several systemic diseases, and absence of defining histopathologic or laboratory findings. Misdiagnosis and delayed diagnosis are common. It has been shown that up to 39% of patients who initially received a diagnosis of PG have an alternative diagnosis.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> In light of this, validated diagnostic criteria have recently been developed for ulcerative pyoderma gangrenosum.<sup id="cite_ref-:0_17-0" class="reference"><a href="#cite_note-:0-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading3"><h3 id="Diagnostic_criteria">Diagnostic criteria</h3></div>

<p>In addition to a biopsy demonstrating a neutrophilic infiltrate, patients must have at least 4 minor criteria to meet diagnostic criteria.<sup id="cite_ref-:0_17-1" class="reference"><a href="#cite_note-:0-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> These criteria are based on histology, history, clinical examination, and treatment.

</p>

<ul><li>Histology: Exclusion of infection (including histologically indicated stains and tissue cultures)</li>

<li>Pathergy (ulcer occurring at sites of trauma, with the ulcer extending past the area of trauma)</li>

<li>Personal history of inflammatory bowel disease or inflammatory arthritis</li>

<li>History of papule, pustule, or vesicle that rapidly ulcerated</li>

<li>Clinical examination (or photographic evidence) of peripheral erythema, undermining border, and tenderness at the site of ulceration</li>

<li>Multiple ulcerations (at least 1 occurring on an anterior lower leg)</li>

<li>Cribriform or “wrinkled paper” scars at sites of healed ulcers</li>

<li>Decrease in ulcer size within 1 month of initiating immunosuppressive medications</li></ul>

<div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2></div>

<p>First-line therapy for disseminated or localized instances of pyoderma gangrenosum is systemic treatment with <a href="Corticosteroids" class="mw-redirect" title="Corticosteroids">corticosteroids</a> and <a href="Ciclosporin" title="Ciclosporin">ciclosporin</a>. Topical application of <a href="Clobetasol" title="Clobetasol">clobetasol</a>, <a href="Mupirocin" title="Mupirocin">mupirocin</a>, and <a href="Gentamicin" title="Gentamicin">gentamicin</a> alternated with <a href="Tacrolimus" title="Tacrolimus">tacrolimus</a> can be effective. Pyoderma gangrenosum ulcers demonstrate <a href="Pathergy" title="Pathergy">pathergy</a>, that is, a worsening in response to minor trauma or surgical debridement. Significant care should be taken with dressing changes to prevent potentially rapid wound growth. Many patients respond differently to different types of treatment, for example, some benefit from a moist environment, so treatment should be carefully evaluated at each stage.

</p><p>If ineffective, alternative therapeutic procedures include systemic treatment with corticosteroids and <a href="Mycophenolate_mofetil" class="mw-redirect" title="Mycophenolate mofetil">mycophenolate mofetil</a>; mycophenolate mofetil and ciclosporin; tacrolimus; <a href="Thalidomide" title="Thalidomide">thalidomide</a>; <a href="Infliximab" title="Infliximab">infliximab</a>; or <a href="Plasmapheresis" title="Plasmapheresis">plasmapheresis</a>.<sup id="cite_ref-pmid16021123_18-0" class="reference"><a href="#cite_note-pmid16021123-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup>

</p>

<ul><li><a href="Superficial_granulomatous_pyoderma" title="Superficial granulomatous pyoderma">Superficial granulomatous pyoderma</a></li>

<li><a href="Brown_recluse_spider_bite" class="mw-redirect" title="Brown recluse spider bite">Brown recluse spider bite</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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</style><cite id="CITEREFJacksonCallen2012" class="citation journal cs1">Jackson JM, Callen JP (April 23, 2012). Elston DM (ed.). <a rel="nofollow" class="external text" href="http://www.emedicine.com/DERM/topic367.htm">"Pyoderma Gangrenosum"</a>. <i>EMedicine</i>.</cite></span>

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<li id="cite_note-Part2018-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-Part2018_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Part2018_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFPartridgeBaiRosenWalsh2018" class="citation journal cs1">Partridge AC, Bai JW, Rosen CF, Walsh SR, Gulliver WP, Fleming P (August 2018). "Effectiveness of systemic treatments for pyoderma gangrenosum: a systematic review of observational studies and clinical trials". <i>The British Journal of Dermatology</i>. <b>179</b> (2): <span class="nowrap">290–</span>295. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fbjd.16485">10.1111/bjd.16485</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29478243">29478243</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:3504429">3504429</a>.</cite></span>

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<li id="cite_note-RuoccoSangiuliano2009-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-RuoccoSangiuliano2009_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-RuoccoSangiuliano2009_3-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><cite id="CITEREFRuoccoSangiulianoGravinaMiranda2009" class="citation journal cs1">Ruocco E, Sangiuliano S, Gravina AG, Miranda A, Nicoletti G (September 2009). "Pyoderma gangrenosum: an updated review". <i>Journal of the European Academy of Dermatology and Venereology</i>. <b>23</b> (9): <span class="nowrap">1008–</span>17. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1468-3083.2009.03199.x">10.1111/j.1468-3083.2009.03199.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19470075">19470075</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:29773727">29773727</a>.</cite></span>

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<li id="cite_note-pmid16021123-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16021123_18-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFReichrathBensBonowitzTilgen2005" class="citation journal cs1">Reichrath J, Bens G, Bonowitz A, Tilgen W (August 2005). "Treatment recommendations for pyoderma gangrenosum: an evidence-based review of the literature based on more than 350 patients". <i>Journal of the American Academy of Dermatology</i>. <b>53</b> (2): <span class="nowrap">273–</span>83. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jaad.2004.10.006">10.1016/j.jaad.2004.10.006</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16021123">16021123</a>.</cite></span>

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<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

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<div class="side-box-text plainlist">Wikimedia Commons has media related to <span style="font-weight: bold; font-style: italic;"><a href="https://commons.wikimedia.org/wiki/Category:Pyoderma_gangrenosum" class="extiw external" title="commons:Category:Pyoderma gangrenosum">Pyoderma gangrenosum</a></span>.</div></div>

</div>

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</style><div id="Neutrophilic_and_eosinophilic_dermatoses103" style="font-size:114%;margin:0 4em">Neutrophilic and eosinophilic dermatoses</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Eosinophilic_dermatosis" title="Eosinophilic dermatosis">Eosinophilic dermatosis</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">With <a href="Vasculitis" title="Vasculitis">vasculitis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Eosinophilic_vasculitis" title="Eosinophilic vasculitis">Eosinophilic vasculitis</a></li>

<li><a href="Eosinophilic_granulomatosis_with_polyangiitis" title="Eosinophilic granulomatosis with polyangiitis">Eosinophilic granulomatosis with polyangiitis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Without vasculitis</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Arthropod_assault" title="Arthropod assault">Arthropod assault</a></li>

<li><a href="Eosinophilic_cellulitis" title="Eosinophilic cellulitis">Eosinophilic cellulitis</a></li>

<li><a href="Hypereosinophilic_syndrome" title="Hypereosinophilic syndrome">Hypereosinophilic syndrome</a></li>

<li><a href="Papuloerythroderma_of_Ofuji" title="Papuloerythroderma of Ofuji">Papuloerythroderma of Ofuji</a></li>

<li><a href="Granuloma_faciale" title="Granuloma faciale">Granuloma faciale</a></li>

<li><a href="Eosinophilic_folliculitis" title="Eosinophilic folliculitis">Eosinophilic folliculitis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Angiolymphoid_hyperplasia_with_eosinophilia" title="Angiolymphoid hyperplasia with eosinophilia">Angiolymphoid hyperplasia with eosinophilia</a>/<a href="Kimura_disease" class="mw-redirect" title="Kimura disease">Kimura's disease</a></li>

<li><a href="Annular_erythema_of_infancy" title="Annular erythema of infancy">Annular erythema of infancy</a></li>

<li><a href="Eosinophilic_fasciitis" title="Eosinophilic fasciitis">Eosinophilic fasciitis</a></li>

<li><a href="Eosinophilic_granuloma" title="Eosinophilic granuloma">Eosinophilic granuloma</a></li>

<li><a href="Eosinophilic_ulcer_of_the_oral_mucosa" title="Eosinophilic ulcer of the oral mucosa">Eosinophilic ulcer of the oral mucosa</a></li>

<li><a href="Erythema_toxicum_neonatorum" title="Erythema toxicum neonatorum">Erythema toxicum neonatorum</a></li>

<li><a href="Incontinentia_pigmenti" title="Incontinentia pigmenti">Incontinentia pigmenti</a></li>

<li><a href="Itchy_red_bump_disease" class="mw-redirect" title="Itchy red bump disease">Itchy red bump disease</a></li>

<li><a href="Juvenile_xanthogranuloma" title="Juvenile xanthogranuloma">Juvenile xanthogranuloma</a></li>

<li><a href="Pachydermatous_eosinophilic_dermatitis" title="Pachydermatous eosinophilic dermatitis">Pachydermatous eosinophilic dermatitis</a></li>

<li><a href="Papular_eruption_of_blacks" title="Papular eruption of blacks">Papular eruption of blacks</a></li>

<li><a href="Pruritic_papular_eruption_of_HIV_disease" title="Pruritic papular eruption of HIV disease">Pruritic papular eruption of HIV disease</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Reactive_neutrophilic_dermatoses" title="Reactive neutrophilic dermatoses">Reactive neutrophilic dermatoses</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Epidermis" title="Epidermis">Epidermis</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Keratoderma_blennorrhagicum" title="Keratoderma blennorrhagicum">Keratoderma blennorrhagicum</a></li>

<li><a href="IgA_pemphigus" title="IgA pemphigus">Subcorneal pustular dermatosis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Dermis" title="Dermis">Dermis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">without <a href="Vasculitis" title="Vasculitis">vasculitis</a>:</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Febrile_neutrophilic_dermatosis" title="Febrile neutrophilic dermatosis">Sweet's syndrome</a></li>

<li><a href="Bowel-associated_dermatosis%E2%80%93arthritis_syndrome" title="Bowel-associated dermatosis–arthritis syndrome">Bowel-associated dermatosis–arthritis syndrome</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">with vasculitis:</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Neutrophilic_dermatosis_of_the_dorsal_hands" title="Neutrophilic dermatosis of the dorsal hands">Neutrophilic dermatosis of the dorsal hands</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Ungrouped</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Erythema_nodosum" title="Erythema nodosum">Acute erythema nodosum</a></li>

<li><a href="Marshall_syndrome" title="Marshall syndrome">Marshall syndrome</a></li>

<li><a href="Neutrophilic_eccrine_hidradenitis" title="Neutrophilic eccrine hidradenitis">Neutrophilic eccrine hidradenitis</a></li>

<li><a href="PAPA_syndrome" title="PAPA syndrome">Pyogenic arthritis–pyoderma gangrenosum–acne syndrome</a></li>

<li><a href="Rheumatoid_neutrophilic_dermatitis" title="Rheumatoid neutrophilic dermatitis">Rheumatoid neutrophilic dermatitis</a></li>

<li><a href="Superficial_granulomatous_pyoderma" title="Superficial granulomatous pyoderma">Superficial granulomatous pyoderma</a></li>

<li><a href="Sweet's_syndrome-like_dermatosis" title="Sweet's syndrome-like dermatosis">Sweet's syndrome-like dermatosis</a></li>

<li><a href="Vesicopustular_dermatosis" title="Vesicopustular dermatosis">Vesicopustular dermatosis</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Cutaneous_keratosis,_ulcer,_atrophy,_and_necrobiosis176" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Cutaneous_keratosis,_ulcer,_atrophy,_and_necrobiosis176" style="font-size:114%;margin:0 4em">Cutaneous keratosis, ulcer, atrophy, and necrobiosis</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Acanthosis" class="mw-redirect" title="Acanthosis">Epidermal thickening</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Keratoderma" title="Keratoderma">keratoderma</a>: <a href="Keratoderma_climactericum" title="Keratoderma climactericum">Keratoderma climactericum</a></li>

<li><a href="Paraneoplastic_keratoderma" title="Paraneoplastic keratoderma">Paraneoplastic keratoderma</a>

<ul><li><a href="Paraneoplastic_acrokeratosis" title="Paraneoplastic acrokeratosis">Acrokeratosis paraneoplastica of Bazex</a></li></ul></li>

<li><a href="Palmoplantar_keratoderma" title="Palmoplantar keratoderma">Aquagenic keratoderma</a></li>

<li><a href="Drug-induced_keratoderma" title="Drug-induced keratoderma">Drug-induced keratoderma</a></li>

<li><i><a href="Psoriasis" title="Psoriasis">psoriasis</a></i>

<ul><li><a href="Keratoderma_blennorrhagicum" title="Keratoderma blennorrhagicum">Keratoderma blennorrhagicum</a></li></ul></li></ul>

<ul><li><a href="Keratosis" title="Keratosis">keratosis</a>: <a href="Seborrheic_keratosis" title="Seborrheic keratosis">Seborrheic keratosis</a>

<ul><li><a href="Clonal_seborrheic_keratosis" class="mw-redirect" title="Clonal seborrheic keratosis">Clonal seborrheic keratosis</a></li>

<li><a href="Common_seborrheic_keratosis" class="mw-redirect" title="Common seborrheic keratosis">Common seborrheic keratosis</a></li>

<li><a href="Irritated_seborrheic_keratosis" class="mw-redirect" title="Irritated seborrheic keratosis">Irritated seborrheic keratosis</a></li>

<li><a href="Seborrheic_keratosis_with_squamous_atypia" class="mw-redirect" title="Seborrheic keratosis with squamous atypia">Seborrheic keratosis with squamous atypia</a></li>

<li><a href="Reticulated_seborrheic_keratosis" class="mw-redirect" title="Reticulated seborrheic keratosis">Reticulated seborrheic keratosis</a></li>

<li><a href="Dermatosis_papulosa_nigra" title="Dermatosis papulosa nigra">Dermatosis papulosa nigra</a></li></ul></li>

<li><a href="Keratosis_punctata_of_the_palmar_creases" title="Keratosis punctata of the palmar creases">Keratosis punctata of the palmar creases</a></li></ul>

<ul><li>other <a href="Hyperkeratosis" title="Hyperkeratosis">hyperkeratosis</a>: <a href="Acanthosis_nigricans" title="Acanthosis nigricans">Acanthosis nigricans</a>

<ul><li><a href="Confluent_and_reticulated_papillomatosis" title="Confluent and reticulated papillomatosis">Confluent and reticulated papillomatosis</a></li></ul></li>

<li><a href="Callus" title="Callus">Callus</a></li>

<li><a href="Ichthyosis_acquisita" title="Ichthyosis acquisita">Ichthyosis acquisita</a></li>

<li><a href="Arsenical_keratosis" title="Arsenical keratosis">Arsenical keratosis</a></li>

<li><a href="Chronic_scar_keratosis" title="Chronic scar keratosis">Chronic scar keratosis</a></li>

<li><a href="Hyperkeratosis_lenticularis_perstans" class="mw-redirect" title="Hyperkeratosis lenticularis perstans">Hyperkeratosis lenticularis perstans</a></li>

<li><a href="Hydrocarbon_keratosis" title="Hydrocarbon keratosis">Hydrocarbon keratosis</a></li>

<li><a href="Hyperkeratosis_of_the_nipple_and_areola" class="mw-redirect" title="Hyperkeratosis of the nipple and areola">Hyperkeratosis of the nipple and areola</a></li>

<li><a href="Inverted_follicular_keratosis" class="mw-redirect" title="Inverted follicular keratosis">Inverted follicular keratosis</a></li>

<li><a href="Lichen_planus" title="Lichen planus">Lichenoid keratosis</a></li>

<li><a href="Multiple_minute_digitate_hyperkeratosis" title="Multiple minute digitate hyperkeratosis">Multiple minute digitate hyperkeratosis</a></li>

<li><a href="PUVA_keratosis" title="PUVA keratosis">PUVA keratosis</a></li>

<li><a href="Reactional_keratosis" title="Reactional keratosis">Reactional keratosis</a></li>

<li><a href="Stucco_keratosis" class="mw-redirect" title="Stucco keratosis">Stucco keratosis</a></li>

<li><a href="Thermal_keratosis" title="Thermal keratosis">Thermal keratosis</a></li>

<li><a href="Wart" title="Wart">Viral keratosis</a></li>

<li><a href="Warty_dyskeratoma" title="Warty dyskeratoma">Warty dyskeratoma</a></li>

<li><a href="Waxy_keratosis_of_childhood" title="Waxy keratosis of childhood">Waxy keratosis of childhood</a></li></ul>

<ul><li>other hypertrophy: <a href="Keloid" title="Keloid">Keloid</a></li>

<li><a href="Hypertrophic_scar" title="Hypertrophic scar">Hypertrophic scar</a></li>

<li><a href="Cutis_verticis_gyrata" title="Cutis verticis gyrata">Cutis verticis gyrata</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Necrobiosis" title="Necrobiosis">Necrobiosis</a>/<a href="Granuloma" title="Granuloma">granuloma</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Granuloma#Necrobiotic/palisading" title="Granuloma">Necrobiotic/palisading</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Granuloma_annulare" title="Granuloma annulare">Granuloma annulare</a>

<ul><li><a href="Perforating_granuloma_annulare" title="Perforating granuloma annulare">Perforating</a></li>

<li><a href="Generalized_granuloma_annulare" title="Generalized granuloma annulare">Generalized</a></li>

<li><a href="Subcutaneous_granuloma_annulare" title="Subcutaneous granuloma annulare">Subcutaneous</a></li>

<li><a href="Granuloma_annulare_in_HIV_disease" class="mw-redirect" title="Granuloma annulare in HIV disease">Granuloma annulare in HIV disease</a></li>

<li><a href="Localized_granuloma_annulare" title="Localized granuloma annulare">Localized granuloma annulare</a></li>

<li><a href="Patch-type_granuloma_annulare" title="Patch-type granuloma annulare">Patch-type granuloma annulare</a></li></ul></li>

<li><a href="Necrobiosis_lipoidica" title="Necrobiosis lipoidica">Necrobiosis lipoidica</a></li>

<li><a href="Annular_elastolytic_giant-cell_granuloma" title="Annular elastolytic giant-cell granuloma">Annular elastolytic giant-cell granuloma</a></li>

<li><a href="Granuloma_multiforme" title="Granuloma multiforme">Granuloma multiforme</a></li>

<li><a href="Necrobiotic_xanthogranuloma" title="Necrobiotic xanthogranuloma">Necrobiotic xanthogranuloma</a></li>

<li><a href="Palisaded_neutrophilic_and_granulomatous_dermatitis" title="Palisaded neutrophilic and granulomatous dermatitis">Palisaded neutrophilic and granulomatous dermatitis</a></li>

<li><a href="Rheumatoid_nodulosis" title="Rheumatoid nodulosis">Rheumatoid nodulosis</a></li>

<li><a href="Interstitial_granulomatous_dermatitis_with_arthritis" title="Interstitial granulomatous dermatitis with arthritis">Interstitial granulomatous dermatitis</a>/<a href="Interstitial_granulomatous_drug_reaction" title="Interstitial granulomatous drug reaction">Interstitial granulomatous drug reaction</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Foreign_body_granuloma" class="mw-redirect" title="Foreign body granuloma">Foreign body granuloma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Beryllium_granuloma" title="Beryllium granuloma">Beryllium granuloma</a></li>

<li><a href="Mercury_granuloma" title="Mercury granuloma">Mercury granuloma</a></li>

<li><a href="Silica_granuloma" title="Silica granuloma">Silica granuloma</a></li>

<li><a href="Silicone_granuloma" title="Silicone granuloma">Silicone granuloma</a></li>

<li><a href="Zirconium_granuloma" title="Zirconium granuloma">Zirconium granuloma</a></li>

<li><a href="Tattoo" title="Tattoo">Tattoo</a></li>

<li><a href="Carbon_stain" title="Carbon stain">Carbon stain</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><i><a href="Eosinophilic_dermatosis" title="Eosinophilic dermatosis">eosinophilic dermatosis</a></i>

<ul><li><a href="Granuloma_faciale" title="Granuloma faciale">Granuloma faciale</a></li></ul></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Dermis" title="Dermis">Dermis</a>/<br>localized <a href="Connective_tissue_disease" title="Connective tissue disease">CTD</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Lupus_erythematosus" title="Lupus erythematosus">Cutaneous lupus<br>erythematosus</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li>chronic: <a href="Discoid_lupus_erythematosus" title="Discoid lupus erythematosus">Discoid</a></li>

<li><a href="Lupus_erythematosus_panniculitis" title="Lupus erythematosus panniculitis">Panniculitis</a></li></ul>

<ul><li><a href="Subacute_cutaneous_lupus_erythematosus" title="Subacute cutaneous lupus erythematosus">subacute</a>: <a href="Neonatal_lupus_erythematosus" title="Neonatal lupus erythematosus">Neonatal</a></li></ul>

<ul><li>ungrouped: <a href="Chilblain_lupus_erythematosus" title="Chilblain lupus erythematosus">Chilblain</a></li>

<li><a href="Lupus_erythematosus%E2%80%93lichen_planus_overlap_syndrome" class="mw-redirect" title="Lupus erythematosus–lichen planus overlap syndrome">Lupus erythematosus–lichen planus overlap syndrome</a></li>

<li><a href="Tumid_lupus_erythematosus" title="Tumid lupus erythematosus">Tumid</a></li>

<li><a href="Verrucous_lupus_erythematosus" title="Verrucous lupus erythematosus">Verrucous</a></li>

<li><a href="Rowell's_syndrome" title="Rowell's syndrome">Rowell's syndrome</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Scleroderma" title="Scleroderma">Scleroderma</a>/<br><a href="Morphea" title="Morphea">Morphea</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Localized_scleroderma" class="mw-redirect" title="Localized scleroderma">Localized scleroderma</a>

<ul><li><a href="Localized_morphea" class="mw-redirect" title="Localized morphea">Localized morphea</a></li>

<li><a href="Morphea%E2%80%93lichen_sclerosus_et_atrophicus_overlap" class="mw-redirect" title="Morphea–lichen sclerosus et atrophicus overlap">Morphea–lichen sclerosus et atrophicus overlap</a></li>

<li><a href="Generalized_morphea" class="mw-redirect" title="Generalized morphea">Generalized morphea</a></li>

<li><a href="Atrophoderma_of_Pasini_and_Pierini" class="mw-redirect" title="Atrophoderma of Pasini and Pierini">Atrophoderma of Pasini and Pierini</a></li>

<li><a href="Pansclerotic_morphea" class="mw-redirect" title="Pansclerotic morphea">Pansclerotic morphea</a></li>

<li><a href="Morphea_profunda" class="mw-redirect" title="Morphea profunda">Morphea profunda</a></li>

<li><a href="Linear_scleroderma" class="mw-redirect" title="Linear scleroderma">Linear scleroderma</a></li></ul></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Atrophy" title="Atrophy">Atrophic</a>/<br><a href="Atrophoderma" title="Atrophoderma">atrophoderma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Lichen_sclerosus" title="Lichen sclerosus">Lichen sclerosus</a></li>

<li><a href="Anetoderma" title="Anetoderma">Anetoderma</a>

<ul><li><a href="Schweninger%E2%80%93Buzzi_anetoderma" class="mw-redirect" title="Schweninger–Buzzi anetoderma">Schweninger–Buzzi anetoderma</a></li>

<li><a href="Jadassohn%E2%80%93Pellizzari_anetoderma" class="mw-redirect" title="Jadassohn–Pellizzari anetoderma">Jadassohn–Pellizzari anetoderma</a></li></ul></li>

<li><a href="Atrophoderma_of_Pasini_and_Pierini" class="mw-redirect" title="Atrophoderma of Pasini and Pierini">Atrophoderma of Pasini and Pierini</a></li>

<li><a href="Acrodermatitis_chronica_atrophicans" title="Acrodermatitis chronica atrophicans">Acrodermatitis chronica atrophicans</a></li>

<li><a href="Lipoatrophia_semicircularis" title="Lipoatrophia semicircularis">Semicircular lipoatrophy</a></li>

<li><a href="Follicular_atrophoderma" title="Follicular atrophoderma">Follicular atrophoderma</a></li>

<li><a href="Linear_atrophoderma_of_Moulin" title="Linear atrophoderma of Moulin">Linear atrophoderma of Moulin</a></li>

<li><a href="Atrophia_maculosa_varioliformis_cutis" title="Atrophia maculosa varioliformis cutis">Atrophia maculosa varioliformis cutis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Cutaneous_perforating_disorders" title="Cutaneous perforating disorders">Perforating</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Kyrle_disease" title="Kyrle disease">Kyrle disease</a></li>

<li><a href="Reactive_perforating_collagenosis" title="Reactive perforating collagenosis">Reactive perforating collagenosis</a></li>

<li><a href="Elastosis_perforans_serpiginosa" title="Elastosis perforans serpiginosa">Elastosis perforans serpiginosa</a></li>

<li><a href="Perforating_folliculitis" title="Perforating folliculitis">Perforating folliculitis</a></li>

<li><a href="Acquired_perforating_dermatosis" title="Acquired perforating dermatosis">Acquired perforating dermatosis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Ulcer_(dermatology)" title="Ulcer (dermatology)">Skin ulcer</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Calcinosis_cutis" title="Calcinosis cutis">Calcinosis cutis</a></li>

<li><a href="Sclerodactyly" title="Sclerodactyly">Sclerodactyly</a></li>

<li><a href="Poikiloderma_vasculare_atrophicans" title="Poikiloderma vasculare atrophicans">Poikiloderma vasculare atrophicans</a></li>

<li><a href="Ainhum" title="Ainhum">Ainhum</a>/<a href="Pseudo-ainhum" class="mw-redirect" title="Pseudo-ainhum">Pseudo-ainhum</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Paraneoplastic_syndromes206" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Paraneoplastic_syndromes206" style="font-size:114%;margin:0 4em"><a href="Paraneoplastic_syndrome" title="Paraneoplastic syndrome">Paraneoplastic syndromes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Endocrine_system" title="Endocrine system">Endocrine</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Hypercalcaemia" title="Hypercalcaemia">Hypercalcaemia</a></li>

<li><a href="Syndrome_of_inappropriate_antidiuretic_hormone_secretion" title="Syndrome of inappropriate antidiuretic hormone secretion">SIADH</a></li>

<li><a href="Zollinger%E2%80%93Ellison_syndrome" title="Zollinger–Ellison syndrome">Zollinger–Ellison syndrome</a></li>

<li><a href="Cushing's_syndrome" title="Cushing's syndrome">Cushing's syndrome</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Haematopoetic_system" class="mw-redirect" title="Haematopoetic system">Hematological</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Multicentric_reticulohistiocytosis" title="Multicentric reticulohistiocytosis">Multicentric reticulohistiocytosis</a></li>

<li><a href="Nonbacterial_thrombotic_endocarditis" title="Nonbacterial thrombotic endocarditis">Nonbacterial thrombotic endocarditis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Neurology" title="Neurology">Neurological</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Paraneoplastic_cerebellar_degeneration" title="Paraneoplastic cerebellar degeneration">Paraneoplastic cerebellar degeneration</a></li>

<li><a href="Encephalomyelitis" title="Encephalomyelitis">Encephalomyelitis</a></li>

<li><a href="Limbic_encephalitis" title="Limbic encephalitis">Limbic encephalitis</a></li>

<li><a href="Opsoclonus" title="Opsoclonus">Opsoclonus</a></li>

<li><a href="Polymyositis" title="Polymyositis">Polymyositis</a></li>

<li><a href="Transverse_myelitis" title="Transverse myelitis">Transverse myelitis</a></li>

<li><a href="Lambert%E2%80%93Eaton_myasthenic_syndrome" title="Lambert–Eaton myasthenic syndrome">Lambert–Eaton myasthenic syndrome</a></li>

<li><a href="Anti-NMDA_receptor_encephalitis" title="Anti-NMDA receptor encephalitis">Anti-NMDA receptor encephalitis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Human_musculoskeletal_system" title="Human musculoskeletal system">Musculoskeletal</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Dermatomyositis" title="Dermatomyositis">Dermatomyositis</a></li>

<li><a href="Hypertrophic_osteopathy" title="Hypertrophic osteopathy">Hypertrophic osteopathy</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Mucocutaneous_zone" class="mw-redirect" title="Mucocutaneous zone">Mucocutaneous</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Reactive <a href="Erythema" title="Erythema">erythema</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Erythema_gyratum_repens" title="Erythema gyratum repens">Erythema gyratum repens</a></li>

<li><a href="Necrolytic_migratory_erythema" title="Necrolytic migratory erythema">Necrolytic migratory erythema</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Papulosquamous_disorder" title="Papulosquamous disorder">Papulosquamous</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Acanthosis_nigricans" title="Acanthosis nigricans">Acanthosis nigricans</a></li>

<li><a href="Ichthyosis_acquisita" title="Ichthyosis acquisita">Ichthyosis acquisita</a></li>

<li><a href="Acrokeratosis_paraneoplastica_of_Bazex" class="mw-redirect" title="Acrokeratosis paraneoplastica of Bazex">Acrokeratosis paraneoplastica of Bazex</a></li>

<li><a href="Extramammary_Paget's_disease" title="Extramammary Paget's disease">Extramammary Paget's disease</a></li>

<li><a href="Florid_cutaneous_papillomatosis" title="Florid cutaneous papillomatosis">Florid cutaneous papillomatosis</a></li>

<li><a href="Leser%E2%80%93Tr%C3%A9lat_sign" title="Leser–Trélat sign">Leser-Trélat sign</a></li>

<li><a href="Pityriasis_rotunda" title="Pityriasis rotunda">Pityriasis rotunda</a></li>

<li><a href="Tripe_palms" title="Tripe palms">Tripe palms</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Febrile_neutrophilic_dermatosis" title="Febrile neutrophilic dermatosis">Febrile neutrophilic dermatosis</a></li>

<li><a href="Paraneoplastic_pemphigus" title="Paraneoplastic pemphigus">Paraneoplastic pemphigus</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table></div></div><div><div class="zim-footer">

This article is issued from <a class="external text" title="Last edited on 2025-07-23" href="https://en.wikipedia.org/wiki/?title=Pyoderma_gangrenosum&oldid=1302171902">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.

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